Environmental changes and changes in life style - caused by rapid development in science and technology - do not provide enough time for human organism to adapt. World Health Organization (WHO) warns that the overload of nervous system and subsequent mental disorders are slowly taking the first place among all other diseases (including cardiovascular and oncological diseases). Prevention of physical and mental disorders is based on adequate balance between mental/physical activities and relaxes of any kind. There is no common guidance what type of recreation and relax should be used. There are general rules, valid only for relatively healthy people - change in the type of activity when compared to the activity during the rest of the year and change of the place of stay during the holiday. For chronically ill people, for whom holiday by the sea, or travelling is not suitable, one of the optimal holiday possibilities is a stay in the spa according to the type of disease. Holiday represents only a short period of year, so it does not give the real chance so far to compensate/cure health consequences of stress and mental exertion. Holiday should be the period of year focused on relax and recreation. On the other hand, we should keep in mind possible risks brought about by life style changes during holiday.