Landscape structure of Slovakia was assessed by application of CORINE land cover database. Inner heterogeneity of the individual land cover classes was analyzed by representation and nature of vegetation formations. This indicator along with natural, and especially geo-relief conditions made possible to estimate eco-stabilizing properties of the individual types of landscape structure in the context of their harmonious functioning. Landscape structure was divided by share of self-regulating properties and demand of societal regulation to three basic groups. Comparison of satellite data from the 1970s and 1990s brought information about landscape changes. Analysis of changes of landscape structure presented the the development and assessment of key landscape types in the context of sustainability. From the viewpoint of strategic decision-making and planning it is necessary to control the landscape changes and to plan the inputs into the environment and regeneration of renewable resources. This contribution was part of the information source for the preparation of the National Strategy of Sustainable Development in the Slovak Republic.