The paper presents the landscape ecological and socioecological research in the region of Trnava. Landscape ecological research is focused on the evaluation of landscape ecosystems, their services, on monitoring of the phenomena and processes occurring in the landscape. Socioecological research is focused on stakeholder’s involvement and the survey of opinions and requests of the citizens for development of the region. The contribution consists from two main parts: (1) information on the research objectives, structure and activities in the region; (2) results of research, particularly changes in the area development during last 30 years.