There is increasing effort in the exploration of complex social and environmental systems to move from examination of individual trends to their comprehensive assessment and predictions using the Global Megatrend concept (GMT). This is defined as a set of trends that influence each other, act on a global scale and have great local impact. The Megatrends are inter-related and they influence social, economic, political, environmental and technological change. This paper assesses the global megatrend implications for Slovakia, and examines megatrends resulting from economic and social trends in the transformation processes influenced by the complex environmental challenges rooted in metabolic contradiction and environmental paradox. Our article then concludes with discussion of megatrends from the perspective of entire system sustainability.