After ten years of the implementation of the Convention on Biological Diversity in the Slovak Republic, a self- assessment project had tried to find an integral synergy-effect and capacity for the implementation of three of UN Conventions – Framework Convention on Climate Change, Convention on Desertification and Convention on Biodiversity. Short description of the historical development and initial steps of the Convention are a part of the contribution and the Convention is presented as a main tool for sustainable life and condition for survival of the human population. Only the general will of human community focused on the implementation of global conventions oriented to the life diversity including our living environment and global ecosystem will help us reach sustainability. Only the scientific credibility and direct support from political level will create relevant data for decisions of the future development and quality of life of the human community. Ignoring or wrong interpretation of scientific messages and visions would lead society to the cumulative state with the protection of biodiversity and the "domino” effect in the global environmental problems. The scientific and technical results, challenges and appeals of two global projects are presented in the article as an example – The Millennium Ecosystem Assessment and Interlinkages between of Biodiversity and Climate Changes organized by the CBD SBSTTA. The results of both activities in which great number of scientific and technical experts participated in all are very important for the meeting of the Millennium Biodiversity Targets 2010 and the main appeal – The halt to the loss of biodiversity by 2010.